The most exciting addition to Nexus Copy Number 9.0 is the new method to estimate copy number from NGS for both shallow/targeted sequencing and normal coverage WGS/WES data. With a nice graphical user interface, the newest version of Nexus Copy Number allows users to easily analyze their data.
Key Features of Version 9.0:
Our new BAM (multiscale reference) method uses a Hidden Markov Model (HMM) to segment the genome. It does so, using coarse binnings in the “backbone” areas to provide copy number base line and large copy number events, as well as fine binnings in “target” areas to provide high resolution copy number detection in targeted regions.
Watch one of our recently recorded webinars or see it in action by filling out the form on this page to request a demo.See what some Early Access Users have already accomplished in version 9.0 with the BAM (multiscale reference) algorithm for CNV estimation from NGS data.
View the webinar recording from Research Scitentis, Shawn Anderson from the Vancouver Prostate Centre, who discussed the challenege for deriving CN from WES of patient derived xenografts and primary prostate tumors lacking benign tissue samples. Furthermore, he also discussed how using Nexus Copy Number 9.0 helps them create a robust pooled reference with the BAM (multiscale reference) algorithm and adjust copy number baseline ploidy.